反应详情

To 29.8 g (0.100 mole) of N-[4-(1-adamantyloxy)phenyl]pyrrolidine dissolved in CH2Cl2 (200 ml) and diethyl ether (25 ml) stirred and cooled in an ice bath is added in one portion 44 ml of 3.4 N HCl in ether (0.15 mole of HCl). After 30 minutes' stirring, the solvent is evaporated. The resulting solid (33.8 g) is recrystallized from CH2Cl2 (120 ml) -- diethyl ether (100 ml) to give 29.0 g of white solid product, mp (in bath at 148°; 1°/minute temperature rise), 163.4°-166.8° C. Nmr, ir, and UV spectra were in accord with the structure.

1. temperaturecooled in an ice bath
2. customthe solvent is evaporated
3. customThe resulting solid (33.8 g) is recrystallized from CH2Cl2 (120 ml)