反应详情

1,2,3,4-Tetrahydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1-naphthalenol (3.0 g, prepared as described in Example 1) is suspended in 50 ml of absolute alcohol and treated with 2.5 ml of 5N ethanolic hydrogen chloride and stirred for 5 to 10 minutes. The mixture is heated on a steam bath for a few minutes and then cooled in ice-water followed by dilution with about 200 ml of ether. The resulting suspension is kept in an ice bath for 10 minutes, after which the precipitate is filtered off and washed with ether to yield 2.44 g of the title compound, melting point 216°-217° C.

1. temperatureThe mixture is heated on a steam bath for a few minutes
2. waitThe resulting suspension is kept in an ice bath for 10 minutes
3. filtrationafter which the precipitate is filtered off
4. washwashed with ether