Hydrochloric Acid → HCID 131711375, compound

HRID 66109Notes

Reaction equation

HRID 66109 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C@H:16]2[CH2:25][CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C@H:17]2[OH:26])[CH2:11][CH2:10]1.[ClH:27]>C(O)C.CCOCC>[ClH:27].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][C@H:16]2[CH2:25][CH2:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C@H:17]2[OH:26])[CH2:11][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54039901cis-1,2,3,4-Tetrahydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1-naphthalenol

Product 1

HCID 131711375HCID 131711375, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 4.1 g of cis-1,2,3,4-tetrahydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1-naphthalenol in 150 ml of absolute ethanol is treated with 4.9 ml of a solution of 4.8 N hydrochloric acid in ether. The mixture is warmed on a steam bath for 15 minutes, cooled and filtered. Recrystallization from ethanol/ether yields 3.5 g of the title compound, melting point 199°-200° C.

Workup

  1. temperatureThe mixture is warmed on a steam bath for 15 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. customRecrystallization from ethanol/ether

Sources & evidence

ORD record
ord-1eb548a606c146e4a043c36fc1694979
Source dataset
uspto-grants-1978_12
Patent number
US04130646

Reaction notes

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