N-bromobutanimide → (S)-N1-(5-(1-methyl-1H-indazol-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine

Participants

Role	Name	HCID	Charge
Reactant	N-bromobutanimide	HCID 67184	—
Reactant	2-Thiazolamine, 4-(trifluoromethyl)-	HCID 1201417	—
Reactant	5-Bromo-4-(trifluoromethyl)-1,3-thiazol-2-amine	HCID 15710701	—
Reactant	(S)-2-amino-3-(4-chlorophenyl)propyl-5-(isoquinolin-6-yl)-4-(trifluoromethyl)thiazol-2-amine	HCID 131729329	—
Product	(S)-N1-(5-(1-methyl-1H-indazol-6-yl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)propane-1,2-diamine	HCID 46880371	—

Reaction Steps

Example 168, N—((S)-2-amino-3-(4-chlorophenyl)propyl-5-(isoquinolin-6-yl)-4-(trifluoromethyl)thiazol-2-amine: The title compound was synthesized in a manner similar manner to that described for Example 165 using 5-bromo-4-(trifluoromethyl)thiazol-2-amine as the starting material which was synthesized by treating 4-(trifluoromethyl)thiazol-2-amine with N-bromosuccinimide. Theoretical (M+H) 463.1 found 463.1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08084479B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-367a3aa61f984213834f8dab6e8fb1a7
Source note	uspto-grants-2011_12