反应详情

1.6 g (5.3 mmol) of methyl 5-(4-ethyl-3-fluorophenyl)-1-formylpiperidine-3-carboxylate were taken up in 10 ml of methanol, and heated to reflux with 1 ml of water and 0.5 ml of concentrated hydrochloric acid for three hours. The reaction mixture was concentrated and dried under reduced pressure. Yield: 1.5 g (63% of theory; purity 68%)

1. temperatureheated
2. concentrationThe reaction mixture was concentrated
3. customdried under reduced pressure