HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenyl chloroformate → 3-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | Methyl 5-(4-ethyl-3-fluorophenyl)piperidine-3-carboxylate | HCID 58116503 | — |
| Product | 3-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate | HCID 58116488 | — |
Reaction Steps
According to General Method 3A, 1.5 g (4.8 mmol) of methyl 5-(4-ethyl-3-fluorophenyl)piperidine-3-carboxylate and 1.3 g (6.3 mmol) of 4-nitrophenyl chloroformate were reacted. Yield: 2.1 g (92% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-7af89bd8e8614da5b46895666b033806 |
| Source note | uspto-grants-2011_12 |