4-Nitrophenyl chloroformate → 3-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate

HRID 661217Notes

Reaction equation

HRID 661217 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][NH:13][CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]2)=[CH:5][C:4]=1[F:19])[CH3:2].Cl[C:21]([O:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=1)=[O:22]>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:21]([O:23][C:24]3[CH:25]=[CH:26][C:27]([N+:30]([O-:32])=[O:31])=[CH:28][CH:29]=3)=[O:22])[CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]2)=[CH:5][C:4]=1[F:19])[CH3:2]

Participants

3

Reactant 2

HCID 821294-Nitrophenyl chloroformateHCID 58116503Methyl 5-(4-ethyl-3-fluorophenyl)piperidine-3-carboxylate

Product 1

HCID 581164883-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate

Procedure

According to General Method 3A, 1.5 g (4.8 mmol) of methyl 5-(4-ethyl-3-fluorophenyl)piperidine-3-carboxylate and 1.3 g (6.3 mmol) of 4-nitrophenyl chloroformate were reacted. Yield: 2.1 g (92% of theory)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7af89bd8e8614da5b46895666b033806
Source dataset
uspto-grants-2011_12
Patent number
US08084469B2

Reaction notes

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