Thiomorpholine → Methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate

HRID 661218Notes

Reaction equation

HRID 661218 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([O:17]C3C=CC([N+]([O-])=O)=CC=3)=O)[CH2:12][CH:11]([C:27]([O:29][CH3:30])=[O:28])[CH2:10]2)=[CH:5][C:4]=1[F:31])[CH3:2].[NH:32]1[CH2:37][CH2:36][S:35][CH2:34][CH2:33]1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:32]3[CH2:37][CH2:36][S:35][CH2:34][CH2:33]3)=[O:17])[CH2:12][CH:11]([C:27]([O:29][CH3:30])=[O:28])[CH2:10]2)=[CH:5][C:4]=1[F:31])[CH3:2]

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 581164883-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate

Product 1

HCID 58116462Methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate

Procedure

According to General Method 5A, 2.2 g (5.0 mmol) of 3-methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate and 2.8 ml (3.1 g, 30.0 mmol) of thiomorpholine were reacted. Yield: 1.2 g (57% of theory)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b32a448733674bc0a92dd6b0c7a999d7
Source dataset
uspto-grants-2011_12
Patent number
US08084469B2

Reaction notes

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