HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiomorpholine → Methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 3-Methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate | HCID 58116488 | — |
| Product | Methyl 5-(4-ethyl-3-fluorophenyl)-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate | HCID 58116462 | — |
Reaction Steps
According to General Method 5A, 2.2 g (5.0 mmol) of 3-methyl 1-(4-nitrophenyl) 5-(4-ethyl-3-fluorophenyl)piperidine-1,3-dicarboxylate and 2.8 ml (3.1 g, 30.0 mmol) of thiomorpholine were reacted. Yield: 1.2 g (57% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-b32a448733674bc0a92dd6b0c7a999d7 |
| Source note | uspto-grants-2011_12 |