HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661230Generated: November 1, 2026
Potassium Carbonate → Methyl 1-(thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate
https://huagongshe.com/reaction/661230
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 3-Methyl 1-(4-nitrophenyl) 5-[4-(trifluoromethyl)phenyl]piperidine-1,3-dicarboxylate | HCID 58002325 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 1-(thiomorpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylate | HCID 58116492 | — |
Reaction Steps
10.0 g (22.1 mmol) of the compound from Example 48A, 6.84 g (66.3 mmol) of thiomorpholine and 9.17 g (66.3 mmol) of potassium carbonate were added to 150 ml of DMF and heated in 10 portions in a single-mode microwave (Emrys Optimizer) at 150° C. for 1 h. For workup, the reaction solutions were combined and filtered, and the residue was purified by means of preparative HPLC. Yield: 5.16 g (55% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084469B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-e9458ef556fd4760ab462ebafbc28bed |
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| Source note | uspto-grants-2011_12 |
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