反应详情

温度

150 °C

10.0 g (22.1 mmol) of the compound from Example 48A, 6.84 g (66.3 mmol) of thiomorpholine and 9.17 g (66.3 mmol) of potassium carbonate were added to 150 ml of DMF and heated in 10 portions in a single-mode microwave (Emrys Optimizer) at 150° C. for 1 h. For workup, the reaction solutions were combined and filtered, and the residue was purified by means of preparative HPLC. Yield: 5.16 g (55% of theory)

1. filtrationfiltered
2. customthe residue was purified by means of preparative HPLC