Potassium tert-butoxide → HCID 58116535, compound

HRID 661241Notes

Reaction equation

HRID 661241 reaction equation
[C:1]([N:4]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)[CH2:7][CH:6]([C:21]([O:23]C)=[O:22])[CH2:5]1)(=[O:3])[CH3:2].CC(C)([O-])C.[K+]>CO>[C:1]([N:4]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([F:18])([F:20])[F:19])=[CH:12][CH:11]=2)[CH2:7][CH:6]([C:21]([OH:23])=[O:22])[CH2:5]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 58116472HCID 58116472, compound

Product 1

HCID 58116535HCID 58116535, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 1.32 g (3.27 mmol) of the compound from Example 63A in methanol (73 ml) were added, at RT, 3.67 g (32.7 mmol) of potassium tert-butoxide. The mixture was stirred at 60° C. overnight. For workup, the methanol was removed under reduced pressure, and the residue was admixed with water and acidified (pH=1) with aqueous 1 N hydrochloric acid solution. The mixture was extracted with ethyl acetate, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 1.19 g (99% of theory)

Workup

  1. customFor workup, the methanol was removed under reduced pressure
  2. extractionThe mixture was extracted with ethyl acetate
  3. dry with materialthe organic phase was dried over magnesium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-c9dbffc238cf4588a2fc80ed758907af
Source dataset
uspto-grants-2011_12
Patent number
US08084469B2

Reaction notes

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