Potassium tert-butoxide → HCID 58116535, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.32 g (3.27 mmol) of the compound from Example 63A in methanol (73 ml) were added, at RT, 3.67 g (32.7 mmol) of potassium tert-butoxide. The mixture was stirred at 60° C. overnight. For workup, the methanol was removed under reduced pressure, and the residue was admixed with water and acidified (pH=1) with aqueous 1 N hydrochloric acid solution. The mixture was extracted with ethyl acetate, and the organic phase was dried over magnesium sulphate, filtered and concentrated under reduced pressure. Yield: 1.19 g (99% of theory)

Provenance & Evidence