反应详情

A solution of 5.73 g (18.2 mmol) of the compound from Example 91A in 116 ml of ethanol was admixed with 1.11 g (0.27 mmol) of platinum oxide, and hydrogenated with 14.3 ml of concentrated hydrochloric acid solution and at RT overnight in a 3.5 bar hydrogen atmosphere. The catalyst was then filtered off through a filter layer and washed repeatedly with ethanol. The combined filtrates were concentrated under reduced pressure. Yield: 5.95 g (100% of theory)

1. customat RT
2. customovernight
3. filtrationThe catalyst was then filtered off through a filter layer
4. washwashed repeatedly with ethanol
5. concentrationThe combined filtrates were concentrated under reduced pressure