Potassium tert-butoxide → 5-[3-Fluoro-4-(trifluoromethoxy)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]2[CH2:18][N:17]([C:19]([N:21]3[CH2:26][CH2:25][S:24][CH2:23][CH2:22]3)=[O:20])[CH2:16][CH:15]([C:27]([O:29]C)=[O:28])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].CC(C)([O-])C.[K+]>>[F:1][C:2]1[CH:3]=[C:4]([CH:13]2[CH2:18][N:17]([C:19]([N:21]3[CH2:26][CH2:25][S:24][CH2:23][CH2:22]3)=[O:20])[CH2:16][CH:15]([C:27]([OH:29])=[O:28])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:10])[F:11]Participants
3
Procedure
According to General Method 4A, 1.95 g (4.329 mmol) of the compound from Example 94A were reacted with 4.86 g (43.3 mmol) of potassium tert-butoxide. Yield: 1.66 g (83% of theory).
Sources & evidence
- ORD record
- ord-8a4ae972953f4a14aa864c1f85a68aee
- Source dataset
- uspto-grants-2011_12
- Patent number
- US08084469B2
Reaction notes
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