HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium tert-butoxide → 5-[3-Fluoro-4-(trifluoromethoxy)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | Methyl 5-[3-fluoro-4-(trifluoromethoxy)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylate | HCID 58116529 | — |
| Product | 5-[3-Fluoro-4-(trifluoromethoxy)phenyl]-1-(thiomorpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58116544 | — |
Reaction Steps
According to General Method 4A, 1.95 g (4.329 mmol) of the compound from Example 94A were reacted with 4.86 g (43.3 mmol) of potassium tert-butoxide. Yield: 1.66 g (83% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-8a4ae972953f4a14aa864c1f85a68aee |
| Source note | uspto-grants-2011_12 |