反应详情

To a solution of 158 mg (0.355 mmol) of the oxadiazole from Example 23A in 2.5 ml of ethanol were added 2.50 ml (19.7 mmol, 40% in water) of dimethylamine solution, and then the reaction mixture was stirred in the microwave at 80 for 1 h. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 94.0 mg (58% of theory)

1. customThe solvent was removed under reduced pressure
2. customthe crude product was purified by means of preparative HPLC