Dimethylamine → {3-[3-(Dimethylamino)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-(morpholin-4-yl)methanone

Participants

Reaction Steps

To a solution of 158 mg (0.355 mmol) of the oxadiazole from Example 23A in 2.5 ml of ethanol were added 2.50 ml (19.7 mmol, 40% in water) of dimethylamine solution, and then the reaction mixture was stirred in the microwave at 80 for 1 h. The solvent was removed under reduced pressure and the crude product was purified by means of preparative HPLC. Yield: 94.0 mg (58% of theory)

Provenance & Evidence