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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661292Generated: November 1, 2026

m-Chloroperbenzoic acid → {3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(1-oxidothiomorpholin-4-yl)methanone

https://huagongshe.com/reaction/661292

Reaction equation

Participants

RoleNameHCIDCharge
Reactantm-Chloroperbenzoic acidHCID 70297—
Reactant{3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanoneHCID 58116577—
Product{3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(1-oxidothiomorpholin-4-yl)methanoneHCID 5811657217.9%

Reaction Steps

60.0 mg (0.116 mmol) of the compound from Example 42 were reacted according to General Method 2 with 36.1 mg (0.105 mmol) of meta-chloroperbenzoic acid. Enantiomer separation of the racemate according to Method 2D gave 10.0 mg of the title compound of Example 43 (enantiomer 1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08084469B2
Source datasetuspto-grants-2011_12
ORD IDord-896cb7ffbed64aaf9dd47710b6721291
Source noteuspto-grants-2011_12