HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → {3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(1-oxidothiomorpholin-4-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | {3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(thiomorpholin-4-yl)methanone | HCID 58116577 | — |
| Product | {3-[3-(2-Methoxyethoxy)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-(1-oxidothiomorpholin-4-yl)methanone | HCID 58116572 | 17.9% |
Reaction Steps
60.0 mg (0.116 mmol) of the compound from Example 42 were reacted according to General Method 2 with 36.1 mg (0.105 mmol) of meta-chloroperbenzoic acid. Enantiomer separation of the racemate according to Method 2D gave 10.0 mg of the title compound of Example 43 (enantiomer 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084469B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-896cb7ffbed64aaf9dd47710b6721291 |
| Source note | uspto-grants-2011_12 |