反应详情

A solution of 7-Bromo-5-methoxy-1H-indole (described in WO 2002028861) in THF was treated with 2 eq. of a solution of n-BuLi in n-hexane (1.6M) at 5° and after 30 min at this temperature was cooled to −75°. Dry ice (excess) was added and after 15 mins the mixture was quenched with H2O and washed with EtOAc. After acidification of the aqueous layer and extraction into CH2Cl2, evaporation gave the desired product.

1. temperaturewas cooled to −75°
2. customwas quenched with H2O
3. washwashed with EtOAc
4. extractionAfter acidification of the aqueous layer and extraction
5. custominto CH2Cl2, evaporation