HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl bromide → Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl bromide | HCID 76965 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate | HCID 16109102 | — |
Reaction Steps
A mixture of EXAMPLE 1A (23.43 g), 2-bromobenzyl bromide (26.24 g), and DIEA (20.94 mL) in acetonitrile (200 mL) at 25° C. was stirred for 2 hours and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084607B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-113da512f3b34f43b7bba10269e473ee |
| Source note | uspto-grants-2011_12 |