HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661348Generated: November 1, 2026
Lithium hydroxide, monohydrate → 4-[4-(4'-Chlorobiphenyl-2-ylmethyl)piperazin-1-YL]benzoic acid
https://huagongshe.com/reaction/661348
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Ethyl 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoate | HCID 16109105 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[4-(4'-Chlorobiphenyl-2-ylmethyl)piperazin-1-YL]benzoic acid | HCID 53434985 | — |
Reaction Steps
A mixture of EXAMPLE 2B (13 g) and lithium hydroxide hydrate (3.78 g) in dioxane (250 mL) and water (100 mL) at 95° C. was stirred for 16 hours and concentrated. The concentrate in water was heated at 80° C. and filtered. The filtrate was treated with 1M HCl (90 mL) and filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084607B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-500227e23589464699e24e35ead9a811 |
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| Source note | uspto-grants-2011_12 |
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