反应详情

A mixture of 6-amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (0.73 g, described in Example 3) and 2N potassium hydroxide (15 ml) is stirred at room temperature for 16 hr. Hydrochloric acid (10%) is added until the solution is acidic. The crystalline precipitate is collected and washed with water and acetone to give the title compound, mp > 270° C.

1. customThe crystalline precipitate is collected
2. washwashed with water and acetone