Hydrochloric Acid → 6-Amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic Acid

HRID 66136Notes

Reaction equation

HRID 66136 reaction equation
C([O:3][C:4]([C:6]1[NH:11][C:10]2[CH:12]=[CH:13][C:14](=[O:18])[C:15]([NH2:17])=[CH:16][C:9]=2[C:8](=[O:19])[CH:7]=1)=[O:5])C.[OH-].[K+].Cl>>[NH2:17][C:15]1[C:14](=[O:18])[CH:13]=[CH:12][C:10]2[NH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8](=[O:19])[C:9]=2[CH:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 537797806-amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 227556146-Amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic Acid

Procedure

A mixture of 6-amino-4,7-dihydro-4,7-dioxo-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (0.73 g, described in Example 3) and 2N potassium hydroxide (15 ml) is stirred at room temperature for 16 hr. Hydrochloric acid (10%) is added until the solution is acidic. The crystalline precipitate is collected and washed with water and acetone to give the title compound, mp > 270° C.

Workup

  1. customThe crystalline precipitate is collected
  2. washwashed with water and acetone

Sources & evidence

ORD record
ord-99d6b7d6e13f47caba6063fa0c227a21
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

Loading…