HCID 178469292, compound → HCID 178481168, compound

HRID 66139Notes

Reaction equation

HRID 66139 reaction equation
C([O:3][C:4]([C:6]1[N:11]([CH3:12])[C:10]2[CH:13]=[C:14]([Br:20])[C:15](=[O:19])[C:16]([OH:18])=[CH:17][C:9]=2[C:8](=[O:21])[CH:7]=1)=[O:5])C>Cl>[Br:20][C:14]1[C:15](=[O:19])[C:16]([OH:18])=[CH:17][C:9]2[C:8](=[O:21])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[N:11]([CH3:12])[C:10]=2[CH:13]=1

Participants

3

Reactant 1

HCID 178469292HCID 178469292, compound

Product 1

HCID 178481168HCID 178481168, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 4,7-dihydro-8-bromo-4,7-dioxo-6-hydroxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (3.6 g, described in Example 9) and concentrated hydrochloric acid (300 ml) is refluxed for 30 min and cooled to room temperature. The precipitate is collected and washed with water to give the title compound, mp > 250° C.

Workup

  1. temperatureis refluxed for 30 min
  2. customThe precipitate is collected
  3. washwashed with water

Sources & evidence

ORD record
ord-2c7964dc2ef74433b34863216ad3564c
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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