反应详情

A mixture of 4,7-dihydro-8-bromo-4,7-dioxo-6-hydroxy-1-methyl-1H-cyclohepta[b]pyridine-2-carboxylic acid ethyl ester (3.6 g, described in Example 9) and concentrated hydrochloric acid (300 ml) is refluxed for 30 min and cooled to room temperature. The precipitate is collected and washed with water to give the title compound, mp > 250° C.

1. temperatureis refluxed for 30 min
2. customThe precipitate is collected
3. washwashed with water