4,7-Dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid → 4,7-Dihydro-4,7-dioxo-6-ethoxy-1H-cyclohepta[b]pyridine-2-carboxylic Acid

HRID 66141Notes

Reaction equation

HRID 66141 reaction equation
[O:1]=[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[N:5](CC)[C:4]2[CH:13]=[CH:14][C:15](=[O:21])[C:16]([O:18][CH2:19][CH3:20])=[CH:17][C:3]1=2>Cl>[O:1]=[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[NH:5][C:4]2[CH:13]=[CH:14][C:15](=[O:21])[C:16]([O:18][CH2:19][CH3:20])=[CH:17][C:3]1=2

Participants

3

Reactant 1

HCID 227556434,7-Dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic Acid

Product 1

HCID 227556034,7-Dihydro-4,7-dioxo-6-ethoxy-1H-cyclohepta[b]pyridine-2-carboxylic Acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 4,7-dihydro-4,7-dioxo-6-ethoxy-1-ethyl-1H-cyclohepta[b]pyridine-2-carboxylic acid (5.3 g, described in Example 13) and 19% hydrochloric acid (50 ml) is refluxed for 1 hr and cooled to room temperature. The precipitate is collected and washed with water to give the title compound, mp > 280° C.

Workup

  1. temperatureis refluxed for 1 hr
  2. customThe precipitate is collected
  3. washwashed with water

Sources & evidence

ORD record
ord-813ce1290e1f401783c37957ab593ba6
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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