Hydrochloric Acid → HCID 135705351, compound

HRID 66144Notes

Reaction equation

HRID 66144 reaction equation
C([O:3][C:4](=[O:25])[CH2:5][N:6]1[C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][C:9](=[O:17])[C:8]2[CH:18]=[C:19]([OH:24])[C:20](=[O:23])C=C[C:7]1=2)C.[OH-].[K+].Cl>>[C:12]([C:11]1[N:6]([CH2:5][C:4]([OH:3])=[O:25])[C:7]2[C:20](=[O:23])[C:19]([OH:24])=[CH:18][C:8]=2[C:9](=[O:17])[CH:10]=1)([OH:14])=[O:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 178472636HCID 178472636, compound

Product 1

HCID 135705351HCID 135705351, compound

Procedure

A mixture of 4,7-dihydro-4,7-dioxo-2-ethoxycarbonyl-6-hydroxy-1H-cyclohepta[b]pyridine-1-acetic acid ethyl ester (1.7 g, described in Example 15) and 1N potassium hydroxide (12 ml) is stirred at room temperature for 2.5 hr. Hydrochloric acid (19%) is added until the mixture is acidic. The precipitate is collected and washed with water, acetone and ether to obtain the title compound, mp > 270° C.

Workup

  1. customThe precipitate is collected
  2. washwashed with water, acetone and ether

Sources & evidence

ORD record
ord-f723d5965d3f4062bb18159442e11eae
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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