反应详情

温度

80 °C

Water (0.1 ml) and sodium tert-butoxide (212 mg) were added to a solution of (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine methane-sulfonate (500 mg) in toluene (2.5 ml) and the mixture was stirred at 80° C. for an hour. Thereto was added water (2.5 ml) and the mixture was stirred at 80° C. for 1.5 hours. The reaction mixture was cooled to room temperature and the organic layer was separated, washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo to give the titled compound.

1. stirringthe mixture was stirred at 80° C. for 1.5 hours
2. temperatureThe reaction mixture was cooled to room temperature
3. customthe organic layer was separated
4. washwashed with a saturated brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo