Water → (2R,4S)-2-Ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine

Participants

Reaction Conditions

Reaction Steps

Water (0.1 ml) and sodium tert-butoxide (212 mg) were added to a solution of (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine methane-sulfonate (500 mg) in toluene (2.5 ml) and the mixture was stirred at 80° C. for an hour. Thereto was added water (2.5 ml) and the mixture was stirred at 80° C. for 1.5 hours. The reaction mixture was cooled to room temperature and the organic layer was separated, washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo to give the titled compound.

Provenance & Evidence