HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4,7-Dihydro-4,7-dioxo-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl ester | HCID 54454156 | — |
| Product | 4,7-Dihydro-4,7-dioxo-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid | HCID 22755599 | — |
Reaction Steps
A mixture of 4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl ester (2.0 g, described in Example 20) and 19% hydrochloric acid (59 ml) is refluxed for 30 minutes and cooled to room temperature. The crystalline precipitate is collected and dried to obtain the title compound, mp 189° (darkens) and 250° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04130649 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-d46247c647e546c8a6fe2748f0339462 |
| Source note | uspto-grants-1978_12 |