反应详情

A mixture of 4,7-dihydro-4,7-dioxo-1-(2-propynyl)-6-(2-propynyloxy)-1H-cyclohepta[b]pyridine-2-carboxylic Acid ethyl ester (2.0 g, described in Example 20) and 19% hydrochloric acid (59 ml) is refluxed for 30 minutes and cooled to room temperature. The crystalline precipitate is collected and dried to obtain the title compound, mp 189° (darkens) and 250° C. (dec).

1. temperatureis refluxed for 30 minutes
2. customThe crystalline precipitate is collected
3. customdried