1,4-Dioxane hydrochloride → HCID 178479650, compound

HRID 661469Notes

Reaction equation

HRID 661469 reaction equation
C([O:8][C:9]1[N:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:11][N:10]=1)C1C=CC=CC=1.[ClH:21].O1CCOCC1>>[ClH:21].[N:15]1([C:12]2[CH:13]=[N:14][C:9]([OH:8])=[N:10][CH:11]=2)[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57972813HCID 57972813, compound

Product 1

HCID 178479650HCID 178479650, compound

Conditions

Temperature
50 °C

Procedure

4N—HCl/dioxane (100 ml) was added to 4-(2-benzyloxy-pyrimidin-5-yl)-morpholine (8.4 g) and the resulting suspension was stirred at 50° C. for an hour. The reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration, washed with hexane, dried to give the titled compound (7.49 g). MS (m/z): 182 [M+H]+.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-74c40b28e82a413684e91538ee0c3af0
Source dataset
uspto-grants-2011_12
Patent number
US08084611B2

Reaction notes

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