HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-hydroxyethyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | HCID 59376005 | HCID 59376005 | — |
| Product | N-(2-hydroxyethyl)-2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | HCID 59376034 | 85% |
Reaction Steps
Similar procedure as Example 2, 2-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (S4) 0.2 g (1.0 mmol) and 2-aminoethanol 0.13 g (2.1 mmol) was reacted. The reaction solution was concentrated and purified by a silica gel column, eluted with CH2Cl2/MeOH (10:1), to give 0.20 g (85%) of the titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084621B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-11aa027a094848cfb6e408ba8c6b4fa9 |
| Source note | uspto-grants-2011_12 |