HCID 70621019, compound → HCID 70621335, compound

HRID 66150Notes

Reaction equation

HRID 66150 reaction equation
C([O:3][C:4]([C:6]1[C:12]2[N:13](C#CC)[CH:14]=[CH:15][C:16](=[O:17])[C:11]=2[C:10]2[CH:21]=[C:22]([CH3:24])[O:23][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])C>Cl>[O:25]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:12]2[NH:13][CH:14]=[CH:15][C:16](=[O:17])[C:11]=2[C:10]2[CH:21]=[C:22]([CH3:24])[O:23][C:9]1=2

Participants

3

Reactant 1

HCID 70621019HCID 70621019, compound

Product 1

HCID 70621335HCID 70621335, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 7,10-dihydro-4,10-dioxo-2-methyl-7-propynyl-4H-furo[3', 2': 3,4]cyclohepta[1,2-b]pyridine-6-carboxylic acid ethyl ester (2.0 g, described in Example 24) and 19% hydrochloric acid (60 ml) is refluxed for 45 minutes and cooled to room temperature. The precipitate of the title compound is collected, washed with acetone and crystallized from pyridine to obtain crystals of the pyridine salt of the title compound, mp 292°-295° C.

Workup

  1. temperatureis refluxed for 45 minutes
  2. customThe precipitate of the title compound is collected
  3. washwashed with acetone
  4. customcrystallized from pyridine

Sources & evidence

ORD record
ord-9a57a109f3c94388958b3b09aeb637fc
Source dataset
uspto-grants-1978_12
Patent number
US04130649

Reaction notes

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