反应详情

A mixture of 7,10-dihydro-4,10-dioxo-2-methyl-7-propynyl-4H-furo[3', 2': 3,4]cyclohepta[1,2-b]pyridine-6-carboxylic acid ethyl ester (2.0 g, described in Example 24) and 19% hydrochloric acid (60 ml) is refluxed for 45 minutes and cooled to room temperature. The precipitate of the title compound is collected, washed with acetone and crystallized from pyridine to obtain crystals of the pyridine salt of the title compound, mp 292°-295° C.

1. temperatureis refluxed for 45 minutes
2. customThe precipitate of the title compound is collected
3. washwashed with acetone
4. customcrystallized from pyridine