Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 661555Generated: October 26, 2026

(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-formyl-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester → HCID 66687943, compound

https://huagongshe.com/reaction/661555

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-formyl-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 86620863—
ReactantHCID 178478192HCID 178478192—
ProductHCID 66687943HCID 66687943—

Reaction Steps

(R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-propyl-2-[(3,4-dichloro-phenyl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was prepared by reaction of 3,4-dichlorophenyl magnesium bromide with (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-formyl-2-propyl-pyrrolidine-1-carboxylic acid tert-butyl ester following the procedure of step 1 of Example 11.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08084623B2
Source datasetuspto-grants-2011_12
ORD IDord-68bbe711260c4143a9fb31cf4346999b
Source noteuspto-grants-2011_12