反应详情

LAH (987 mg, 26 mmol) was added slowly to a solution of 2-amino-6-fluoro-benzoic acid (2.69 g, 17.3 mmol) in dry THF (20 mL) at 0° C. The mixture was stirred at room temperature for approximately 1 hr and cooled to 0° C. again. Na2SO410H2O (10 g) was added slowly with stirring for 20 minutes. The mixture was filtered, the solid was washed with THF. The solution was concentrated to yield a yellow solid as (2-amino-6-fluoro-phenyl)-methanol (2.49 g). MS [M−OH]+: 124.1; tR=0.57 min. (method 1)

1. temperaturecooled to 0° C. again
2. additionNa2SO410H2O (10 g) was added slowly
3. stirringwith stirring for 20 minutes
4. filtrationThe mixture was filtered
5. washthe solid was washed with THF
6. concentrationThe solution was concentrated