反应详情

温度

-78 °C

N-[2-(t-butyldimethylsilanyloxy)-ethoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-[(2-oxo-ethoxyimino)-methyl]-benzamide (60 mg, 0.092 mmol) prepared in Process A was dissolved in anhydrous tetrahydrofuran (2.0 mL) under an argon atmosphere. This reaction solution was cooled to −78° C., and then 0.93 M methyl magnesium bromide (0.25 mL) was added thereto. The reaction solution was allowed to gradually warm to room temperature, and stirred for eight hours. The reaction was quenched with saturated aqueous solution of ammonium chloride, and the solution was extracted with ethyl acetate.

1. temperatureto gradually warm to room temperature
2. customThe reaction was quenched with saturated aqueous solution of ammonium chloride
3. extractionthe solution was extracted with ethyl acetate