HRID661727

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(/C=N/OCCO)c(F)c2F)c(F)c1

HCID11430524

未命名化合物

结构：CNC(=O)CCON=Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)c(F)c1F

HCID72818303

未命名化合物

2 次

HCID72958466

未命名化合物

PRODUCTS

生成物

结构：C#Cc1ccc(Nc2c(C(=O)NOCCO)cc(/C=N/OCCC(=O)NC)c(F)c2F)c(F)c1

HCID11260110

未命名化合物

PROCEDURE

实验过程

This compound was synthesized from 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-methylcarbamoyl-ethoxyimino)-methyl]-benzamide (Example 14, Compound 14), and the actual reaction was carried out according to the method for manufacturing 2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide (Example 2, Compound 2).

WORKUP

后处理

customthe actual reaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-20cd3c74bfdc400f850c11702e0c6c02
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08084645B2
来源说明: uspto-grants-2011_12

反应 SMILES

[F:1][C:2]1[C:3]([NH:25][C:26]2[CH:31]=[CH:30][C:29](I)=[CH:28][C:27]=2[F:33])=[C:4]([CH:12]=[C:13]([CH:16]=[N:17][O:18][CH2:19][CH2:20][C:21](=[O:24])[NH:22][CH3:23])[C:14]=1[F:15])[C:5]([NH:7][O:8][CH2:9][CH2:10][OH:11])=[O:6].[C:34](C1C=CC(NC2C(F)=C(F)C(C=NOCCO)=CC=2C(NOCCO)=O)=C(F)C=1)#[CH:35].C(C1C=CC(NC2C(F)=C(F)C(/C=N/OCCO)=CC=2C(NOCCO)=O)=C(F)C=1)#C>>[C:34]([C:29]1[CH:30]=[CH:31][C:26]([NH:25][C:3]2[C:2]([F:1])=[C:14]([F:15])[C:13](/[CH:16]=[N:17]/[O:18][CH2:19][CH2:20][C:21](=[O:24])[NH:22][CH3:23])=[CH:12][C:4]=2[C:5]([NH:7][O:8][CH2:9][CH2:10][OH:11])=[O:6])=[C:27]([F:33])[CH:28]=1)#[CH:35]