2-[(4-Ethynyl-2-Fluorophenyl)amino]-3,4-Difluoro-N-(2-Hydroxyethoxy)-5-{[(2-Hydroxyethoxy)imino]methyl}benzamide → 2-(4-ethynyl-2-fluoroanilino)-3,4-difluoro-N-(2-hydroxyethoxy)-5-[(E)-[3-(methylamino)-3-oxopropoxy]iminomethyl]benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-[(4-Ethynyl-2-Fluorophenyl)amino]-3,4-Difluoro-N-(2-Hydroxyethoxy)-5-{[(2-Hydroxyethoxy)imino]methyl}benzamide	HCID 11430524	—
Reactant	3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-methylcarbamoyl-ethoxyimino)-methyl]-benzamide	HCID 72818303	—
Reactant	2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide	HCID 72958466	—
Product	2-(4-ethynyl-2-fluoroanilino)-3,4-difluoro-N-(2-hydroxyethoxy)-5-[(E)-[3-(methylamino)-3-oxopropoxy]iminomethyl]benzamide	HCID 11260110	—

Reaction Steps

This compound was synthesized from 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-methylcarbamoyl-ethoxyimino)-methyl]-benzamide (Example 14, Compound 14), and the actual reaction was carried out according to the method for manufacturing 2-(4-ethynyl-2-fluoro-phenylamino)-3,4-difluoro-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide (Example 2, Compound 2).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08084645B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-20cd3c74bfdc400f850c11702e0c6c02
Source note	uspto-grants-2011_12