Sodium Chloride → HCID 69128686, compound

HRID 661759Notes

Reaction equation

HRID 661759 reaction equation
[C:1]1([N:7]=[C:8]([S:15][CH:16]([CH3:18])[CH3:17])[CH2:9][CH2:10][Si](C)(C)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].[Cl-].[Na+]>CO>[C:1]1([N:7]=[C:8]([S:15][CH:16]([CH3:17])[CH3:18])[CH2:9][CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 5234Sodium ChlorideHCID 11430Potassium CarbonateHCID 69127194HCID 69127194, compound

Product 1

HCID 69128686HCID 69128686, compoundYield 92.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Isopropyl N-phenyl-3-(trimethylsilyl)thiopropioimidate (1.6 g) was dissolved to methanol (50 ml), small amount of potassium carbonate was added thereto under ice-cooling, then stirred for 30 minutes. The reaction solution was poured into aqueous solution of sodium chloride, and it was extracted with ethyl acetate. The organic layer was washed with water, dried and distilled off the solvent to obtain isopropyl N-phenyl-thiopropioimidate (1.1 g).

Workup

  1. additionwas added
  2. temperatureunder ice-cooling
  3. extractionwas extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. customdried
  6. distillationdistilled off the solvent

Sources & evidence

ORD record
ord-f6eee43dc3404bcdbed8c255084461c7
Source dataset
uspto-grants-2011_12
Patent number
US08084644B2

Reaction notes

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