3,5-Dimethylbiphenyl-4-ylboronic acid → HCID 178476522, 화합물

HRID 661786노트

반응식

HRID 661786 반응식
[C:1]([O-:4])(=[O:3])[CH3:2].[C:5]([O-:8])(=[O:7])[CH3:6].[C:9]([O-:12])(=[O:11])[CH3:10].C([O-])(=O)C.[Pb+4:17].[CH3:18][C:19]1[C:24](B(O)O)=[C:23]([CH3:28])[CH:22]=[C:21]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:20]=1>C(Cl)(Cl)Cl>[C:1]([O-:4])(=[O:3])[CH3:2].[C:5]([O-:8])(=[O:7])[CH3:6].[C:9]([O-:12])(=[O:11])[CH3:10].[CH3:18][C:19]1[C:24]([Pb+3:17])=[C:23]([CH3:28])[CH:22]=[C:21]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:20]=1

참가 물질

4

반응물 2

HCID 594504813,5-Dimethylbiphenyl-4-ylboronic acidHCID 178418268HCID 178418268, 화합물

생성물 1

HCID 178476522HCID 178476522, 화합물수율 67.7%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
40 °C

실험 절차

To a solution of lead tetraacetate (4.3 g, 9.7 mmol) in dry chloroform (15 ml) at 40° C. is added 3,5-dimethylbiphen-4-ylboronic acid (2.0 g; 8.8 mmol) in one portion under an atmosphere of nitrogen. The mixture is stirred at 40° C. for 4 hours, and then is cooled to room temperature. The precipitate is removed by filtration, and the filtrate is then passed through a plug of potassium carbonate supported on diatomaceous earth to remove acetic acid. The filtrate is evaporated in vacuo to afford 3,5-dimethylbiphen-4-yllead triacetate (3.37 g).

후처리

  1. temperatureis cooled to room temperature
  2. customThe precipitate is removed by filtration
  3. customto remove acetic acid
  4. customThe filtrate is evaporated in vacuo

출처 및 근거

ORD 기록
ord-ccc8f4cff2954bd4bff0265be786637a
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084649B2

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