反应详情

温度

130 °C

To 1,1-dimethylethyl 4-[(3-bromophenyl)methylidene]-1-piperidinecarboxylate (2.11 g, 5.99 mmol) in 1,4-dioxane (30 mL) and water (10.00 mL) was added m-NC(C6H4)B(OH)2 (1.056 g, 7.19 mmol), Pd(Ph3P)4 0.277 g, 0.240 mmol), K2CO3 (2.483 g, 17.97 mmol). The resulting mixture was split into two equal portions and each portion was heated in a microwave at about 130° C. for about 15 min. The reaction mixture was evaporated using a Glas-Col evaporator and purified with CombiFlash chomatograph to afford the title compound (1.93 g, 86%). LC-MS m/z 749 (2M+H)+.

1. customThe resulting mixture was split into two equal portions
2. customThe reaction mixture was evaporated
3. customa Glas-Col evaporator
4. custompurified with CombiFlash chomatograph