Water → tert-Butyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

HRID 662185Notes

Reaction equation

[CH3:1][CH:2]([CH2:3][AlH:4][CH2:5][CH:6]([CH3:7])[CH3:8])[CH3:9].[Cl:29][CH2:30][Cl:31].[O:10]=[C:11]1[O:12][CH2:13][CH2:14][C:15]12[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2.[OH2:28]>>[OH:10][CH2:11][C:15]1([CH2:14][CH2:13][OH:12])[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]1

Participants

Reactant 4

HCID 962Water

HCID 6344Dichloromethane

HCID 14487Diisobutylaluminum hydride

HCID 10015228Tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

Product 1

HCID 21955304tert-Butyl 4-(2-hydroxyethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Sources & evidence

ORD record: ord-42184f9bce1248c8913e996bded1bc33
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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