Tetrahydrofuran → 4-(5-{2-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-propyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

HRID 662187Notes

Reaction equation

HRID 662187 reaction equation
[Br:19][CH:20]([CH3:21])[c:22]1[n:23][o:24][c:25](-[c:27]2[cH:28][c:29]([Cl:33])[cH:30][cH:31][cH:32]2)[n:26]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[CH3:6][n:7]1[c:8](-[c:13]2[cH:14][cH:15][n:16][cH:17][cH:18]2)[n:9][n:10][c:11]1[CH3:12]>>[CH3:6][n:7]1[c:8](-[c:13]2[cH:14][cH:15][n:16][cH:17][cH:18]2)[n:9][n:10][c:11]1[CH2:12][CH:20]([CH3:21])[c:22]1[n:23][o:24][c:25](-[c:27]2[cH:28][c:29]([Cl:33])[cH:30][cH:31][cH:32]2)[n:26]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11600754Pyridine, 4-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-HCID 578379313-(1-Bromo-ethyl)-5-(3-chloro-phenyl)-[1,2,4]oxadiazoleHCID 178418339Butyllithium

Product 1

HCID 596673664-(5-{2-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-propyl}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

Sources & evidence

ORD record
ord-1c6d4677eaf043868b6992d0534bcd53
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…