Hydrochloric Acid → HCID 70604051, compound

HRID 66230Notes

Reaction equation

HRID 66230 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[N:12]=[C:13]([C:15]([O:17]C)=[O:16])[CH:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1.Cl>CC(C)=O>[OH2:16].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[N:12]=[C:13]([C:15]([OH:17])=[O:16])[CH:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:6]=2[CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 123778848-Chloro-6-phenyl-4H-pyrazolo[1,5-a][1,4]benzodiazepine-2-carboxylic acid, methyl ester

Product 1

HCID 70604051HCID 70604051, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1.05 g. (3 mmol) of the end product of Example 9 in 3 ml. acetone and 30 ml. of 1N HCl was heated to reflux for 2 hours. After cooling to room temperature, the mixture was concentrated in vacuo and the residue recrystallized twice from H2O/acetone/ether to give analytically pure end product as off-white prisms: mp 268°-269°.

Workup

  1. additionA mixture of 1.05 g
  2. temperatureto reflux for 2 hours
  3. concentrationthe mixture was concentrated in vacuo
  4. customthe residue recrystallized twice from H2O/acetone/ether
  5. customto give analytically pure end product as off-white prisms

Sources & evidence

ORD record
ord-a4975ab770b848c5afc81395fdfeba8c
Source dataset
uspto-grants-1978_12
Patent number
US04130716

Reaction notes

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