Ethanol → {[2-Hydroxy-4-methoxy-alpha-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester

HRID 66246ノート

反応式

HRID 66246 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:18])[C:9]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=2[OH:17])=[CH:4][CH:3]=1.C(O)C.Cl.[CH2:23]([O:25][C:26](=[O:34])[CH:27](N)[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:24]>N1C=CC=CC=1>[CH2:23]([O:25][C:26](=[O:34])[CH:27]([N:18]=[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:10]=1[OH:17])[C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:24]

参加物

5

反応物 3

HCID 702EthanolHCID 3084143Propanedioic acid, 2-amino-, 1,3-diethyl ester, hydrochloride (1:1)HCID 1363884104'-Chloro-2-hydroxy-4-methoxy-benzophenone imine

生成物 1

HCID 136388411{[2-Hydroxy-4-methoxy-alpha-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

10.5 G. of 4'-chloro-2-hydroxy-4-methoxy-benzophenone imine in 60 ml. of ethanol is reacted with 12.6 g. of aminomalonic acid diethyl ester hydrochloride and 5.0 ml. of pyridine in accordance with the procedure described in Example 2. After a single recrystallization of the crude product from ethanol, there is obtained {[2-hydroxy-4-methoxy-α-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester, having a melting point of 73°-75° C.

後処理

  1. customAfter a single recrystallization of the crude product from ethanol

出典と根拠

ORDレコード
ord-4a07e1019d9444c2bd47b7ce904726ca
出典データセット
uspto-grants-1978_12
特許番号
US04130717

反応ノート

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