Hydrochloric Acid → 1-(2-Hydroxyethyl)-2,6-diethyl-2,3,6-trimethylpiperidine
Reaction equation
[CH2:1]([C:3]1([CH3:13])[CH:8]([CH3:9])[CH2:7][CH2:6][C:5]([CH2:11][CH3:12])([CH3:10])[NH:4]1)[CH3:2].Cl.[CH2:15]1[O:17][CH2:16]1>CO>[OH:17][CH2:16][CH2:15][N:4]1[C:5]([CH2:11][CH3:12])([CH3:10])[CH2:6][CH2:7][CH:8]([CH3:9])[C:3]1([CH2:1][CH3:2])[CH3:13]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
An autoclave is filled with 36.6 g 2,6-diethyl-2,3,6-trimethylpiperidine, 150 ml of methanol and 1 ml conc. hydrochloric acid. 11 g of ethylene oxide are added under a pressure of 2 atmospheres and the autoclave is heated to 100° C. for 24 hours. The methanol is distilled off and the residue is purified by fractional distillation which yields 1-(2-hydroxyethyl)-2,6-diethyl-2,3,6-trimethylpiperidine (Compound No. 8) boiling at 106° C./0.1 mm Hg.
Workup
- distillationThe methanol is distilled off
- distillationthe residue is purified by fractional distillation which
Sources & evidence
- ORD record
- ord-6e1ea5acf66642c2ad3482a3db0c094a
- Source dataset
- uspto-grants-1978_12
- Patent number
- US04131599
Reaction notes
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