HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(4-Chlorophenoxy)-N-(2-cyanoethyl)-2-methylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | N-cyanoethyl alpha-bromo-isobutyramide | HCID 54029148 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(4-Chlorophenoxy)-N-(2-cyanoethyl)-2-methylpropanamide | HCID 71371061 | — |
Reaction Steps
Into a 25 liter reactor fitted with cooling and stirring means there were poured 3 liters of ethanol, 60 g of sodium and 250 g of p-chlorophenol (1.944 mol). After stirring for 1 hour there were added 3 liters of toluene and the ethanol/toluene azeotrope was removed by distillation; 2 more liters of toluene were added and also 425 g of N-cyanoethyl α -bromo-isobutyramide, (1.944 mol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04131617 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-39df1e5f7f404323818a74e6bd196d9e |
| Source note | uspto-grants-1978_12 |