Chloride → 5-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

HRID 662536Notes

Reaction equation

HRID 662536 reaction equation
[Cl-:1].[F:6][C:7]1([F:19])[O:8][c:9]2[c:10]([cH:12][cH:13][c:14]([C:16]([OH:17])=[O:18])[cH:15]2)[O:11]1.[S:2]([Cl:3])([Cl:4])=[O:5]>>[Cl:1][CH2:16][c:14]1[cH:13][cH:12][c:10]2[c:9]([cH:15]1)[O:8][C:7]([F:6])([F:19])[O:11]2

Participants

4

Reactant 3

HCID 312ChlorideHCID 24386Thionyl ChlorideHCID 6087722,2-Difluoro-1,3-benzodioxole-5-carboxylic acid

Product 1

HCID 219928095-(Chloromethyl)-2,2-difluorobenzo[d][1,3]dioxole

Sources & evidence

ORD record
ord-897382c3048d48bcba847a1053289b19
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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