Dimethylformamide → [4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(piperazin-2-one-4-yl-methyl)-piperidin-1-yl]-methanone

HRID 662547Notes

Reaction equation

HRID 662547 reaction equation
[CH3:50][N:51]([CH3:52])[CH:53]=[O:54].[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]2[N:16]=[C:17]([c:37]3[c:38]([O:47][CH2:48][CH3:49])[cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]3)[N:18]([C:27](=[O:28])[N:29]3[CH2:30][CH2:31][CH:32]([CH2:35][Br:36])[CH2:33][CH2:34]3)[CH:19]2[c:20]2[cH:21][cH:22][c:23]([Cl:26])[cH:24][cH:25]2)[cH:13][cH:14]1.[NH:1]1[C:2](=[O:7])[CH2:3][NH:4][CH2:5][CH2:6]1>>[NH:1]1[C:2](=[O:7])[CH2:3][N:4]([CH2:35][CH:32]2[CH2:31][CH2:30][N:29]([C:27]([N:18]3[C:17]([c:37]4[c:38]([O:47][CH2:48][CH3:49])[cH:39][c:40]([C:43]([F:44])([F:45])[F:46])[cH:41][cH:42]4)=[N:16][CH:15]([c:12]4[cH:11][cH:10][c:9]([Cl:8])[cH:14][cH:13]4)[CH:19]3[c:20]3[cH:21][cH:22][c:23]([Cl:26])[cH:24][cH:25]3)=[O:28])[CH2:34][CH2:33]2)[CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 231360Piperazin-2-oneHCID 86595530[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-bromomethyl-piperidin-1-yl]-methanone

Product 1

HCID 69273762[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(piperazin-2-one-4-yl-methyl)-piperidin-1-yl]-methanone

Sources & evidence

ORD record
ord-7925d8aa3d0d485287e6636524db4967
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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