反应详情

温度

45 °C

22 parts of 2,6-lutidine are added in the course of 15 minutes, at from -5 to +5° C., to a mixture of 50 parts of N-chloromethyl-N-cyclohexylsulfamic acid chloride in 110 parts of cyclohexane and 55 parts of methanol. The reaction mixture is stirred for 20 minutes at 25° C. and one hour at 45° C. After concentrating the solvent under reduced pressure and removing the hydrochloride which has precipitated, distillation gives 30 parts (60% of theory) of N-methoxymethyl-N-cyclohexylsulfamic acid chloride of boiling point 102-106° C./0.01 mbar and nD25 = 1.4857.

1. concentrationAfter concentrating the solvent under reduced pressure
2. customremoving the hydrochloride which
3. customhas precipitated
4. distillationdistillation